Alpha-ketoglutaric acid (-KG), also known as 2-oxoglutaric acid or -ketoglutarate (-KG), is a critical intermediary molecule in cellular energy and amino acid metabolism. It is a naturally occurring organic acid that is necessary for the Krebs cycle, commonly known as the citric acid cycle or the tricarboxylic acid cycle.
Alpha-ketoglutaric acid functions as a coenzyme and is involved in a variety of enzymatic processes. It participates in transamination processes, which entail the conversion of amino acids to their equivalent alpha-keto acids. It also acts as a precursor in the manufacture of glutamate, a non-essential amino acid.
In addition to its involvement in amino acid metabolism, alpha-ketoglutaric acid has gained popularity as a dietary supplement due to its possible health advantages. It is said to help with energy production, muscular rehabilitation, and workout performance. Supplementing with alpha-ketoglutaric acid may potentially have antioxidant qualities and benefit general cellular health.
In addition, alpha-ketoglutaric acid is used in the food sector as a flavour enhancer and acidity regulator. It is used to improve the taste and stability of processed foods and beverages.
In conclusion, alpha-ketoglutaric acid is a critical intermediary molecule in cellular metabolism, especially in energy synthesis and amino acid metabolism. It offers potential health benefits and can be used in the food sector.
AKG is a critical intermediate in the Krebs cycle, which is the process by which cells generate energy by breaking down glucose and other molecules. The non-salt form of AKG is alpha-ketoglutaric free acid, which is more easily absorbed by the body and thus frequently used in dietary supplements. AKG free acid is a popular sports nutrition supplement because it has been shown to improve athletic performance and muscle recovery. It is thought to work by increasing ATP production, the primary energy source for cells, and by promoting glutamine synthesis, an amino acid that aids in the repair and rebuilding of muscle tissue. AKG free acid may also benefit cellular health by increasing antioxidant activity and decreasing oxidative stress, according to research. AKG free acid has also been investigated for its potential role in improving cognitive function and reducing fatigue symptoms in patients suffering from chronic fatigue syndrome. The potential use of AKG free acid in cancer treatment has also been investigated. According to research, AKG free acid may help inhibit the growth of cancer cells and improve the effectiveness of chemotherapy.
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